WebOct 11, 2024 · “CHEK2 is a gene that provides the instructions for a protein, checkpoint kinase 2, that repairs DNA when it is damaged and suppresses tumor formation,” Dr. … WebOct 11, 2024 · The most well-known of these is the BRCA genes although there are several related genes, including the CHEK2 gene. “CHEK2 works along the same general DNA repair pathway and thus also increases ...
CHEK2 checkpoint kinase 2 - NIH Genetic Testing Registry (GTR)
Web89.6.5 CHEK2. CHEK2 produces a checkpoint kinase protein, activated in response to radiation and other agents that cause breaks in the DNA. CHK2 (or CHEK2) functions broadly comparable to ATM, has been implicated in some instances of LFS and is considered a low-penetrance breast cancer gene. CHEK2 was dubbed the breast–colon … WebJun 1, 2013 · We also found an association of the CHEK2 I157T variant with familial cases (OR=1.85, 95% CI=1.51-2.26, p<0.00001). However, the association was not established for other types of cancer (OR=1.09 ... how to remove mold from beauty blender
Cancer risk management and CHEK2 gene mutations
WebJul 7, 2024 · INTRODUCTION. This monograph summarizes the interpretation of germline testing of the CHEK2 gene. It does not discuss indications for testing and is not intended to replace clinical judgment in the decision to test or in the clinical care of the individual who was tested. These subjects are discussed separately [ 1 ]. WebAbout CHEK2. CHEK2 genes are tumor-suppressor genes that help prevent cells from growing and dividing too fast or in an uncontrolled way.A pathogenic variant in the CHEK2 gene affects the growth and function of a cell. Individuals with a pathogenic variant in the CHEK2 gene are at an increased risk for developing breast and colon cancer.. Cancer … WebAug 23, 2024 · What Is the CHEK2 Gene? Checkpoint kinase 2, or CHEK2, for short, is a gene that normally helps with DNA repair. If you have a mutation, or variation, in this gene, you may be at an increased... how to remove mold from bamboo cutting board