Cisplatin kidney toxicity

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August undefined, 2024

WebAug 1, 2024 · Cisplatin can also cause direct nephrotoxicity as it accumulates within the renal epithelial cells leading to DNA damage and release of damage associated molecular patterns (DAMPs). As a consequence, cytokines and inflammatory cells are … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose …

Pathophysiologic Mechanisms of Selected Types of Nephrotoxicity - Medscape

WebMar 22, 2024 · They exert their main toxic effect within the tubular cell by altering phospholipid metabolism. In addition to their direct effect on cells, aminoglycosides cause renal vasoconstriction. The 2... cs15ac1i

Natural products: potential treatments for cisplatin-induced ...

WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various … WebBoth in animals and humans, a variety of agents appear to alter renal uptale of cisplatin and its hemodynamic consequences, thus modulating nephrotoxicity. Thiosulfates and … WebHowever, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal … cs1591 warning

Cisplatin dose adjustment in patients with renal impairment, …

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

WebThe nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure, chronic kidney disease, uremia, and hypertensive nephropathy. WebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. cs1591 missing xml commentWebOct 7, 2024 · 3. Cisplatin Nephrotoxicity. Experimental nephrotoxicity, first reported in 1971 [], is the most frequently studied cisplatin side effect.Over the past decades, researchers have demonstrated that cisplatin can cause nephrotoxicity or acute kidney injury (AKI) of varying severity in a dose-dependent manner [].Depending on the dose (single or … cs15ac1w

"WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and hematological toxicity … " - Cisplatin kidney toxicity

Cisplatin kidney toxicity

Modulation of Oxidative Stress by Ozone Therapy in the …

WebMay 18, 2024 · The high incidence of cisplatin-induced nephrotoxicity in elderly patients may be associated with renal hypoperfusion; increased comorbidities, such as chronic … WebIntroduction. Cisplatin (cis-diamminedichloroplatinum(II)) is one of the most widely used first-line chemotherapeutic agents for a broad range of cancers.Cisplatin continues to be in widespread clinical use for various solid tumors such as ovarian, testicular, bladder, head and neck, and non-small cell lung cancers 1,2 but its usefulness is limited due to its high …

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WebSep 1, 2024 · Rucaparib was the most potent radiosensitiser and VE-821 was the most potent chemosensitiser. VE-821, PF-47736 and MK-1775 attenuated cisplatin-induced S-phase arrest but tended to increase G2 phase accumulation. In mice, cisplatin-induced acute kidney injury was associated with oxidative stress and PARP activation and was … WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with …

WebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also … WebCisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after …

WebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. … WebCisplatin can affect the kidneys. You will be given extra fluids through the drip before and after the cisplatin. You may also have a drug called mannitol. The fluids and mannitol can help prevent kidney damage. Your nurse will explain how long this will take. Your course of …

WebWARNING: Cisplatin may cause severe kidney problems, nerve problems, and severe nausea and vomiting. Nerve problems may occur during treatment or weeks after …

WebCisplatin is a potent tubular toxin with a high incidence of nephrotoxicity. Carboplatin is considered less nephrotoxic but can still cause tubular injury and interstitial nephritis in patients who have been previously treated with cisplatin. dynamic thermostatic radiator valveWebApr 12, 2024 · Evaluation of the effect of glycine infusions on the early renal uptake of cisplatin. Kidney platinum content was markedly lower in rats who had received glycine infusion compared to control rats who had received saline-infusion. ... Klastersky, J. Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin … cs 159 what langaueWebNov 26, 2024 · In this way, HO-1 expression has been effectively described as a modulator of cisplatin-induced renal toxicity and its increase as a potential approach for decreasing kidney injury [49,50]. As described in these works, rectal O 3 /O 2 insufflation at appropriated concentrations enhances the antioxidant mechanisms in renal tissue, which … c.s. 154 harriet tubman learning centerWebAug 5, 2024 · However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicity involve oxidative stress, inflammation, and renal fibrosis, which are covered in this short review. cs159 hw04WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … cs15ac1-wWebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known … cs15ac3wWebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. cs 159 purdue textbook