Hcc serum marker

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August undefined, 2024

WebAbstact. Golgi protein-73 (GP73) is up-regulated in hepatocellular carcinoma (HCC). The aims of this study were to determine if GP73 is detected in the serum, and to establish the sensitivity and specificity of serum GP73 for diagnosing HCC. Serum GP73 was detected by immunoblots and quantified by densitometric analysis. WebHepatocellular carcinoma (HCC) accounts for a significant and increasing burden of disease globally. 1 Challenges exist to improve outcomes for patients with HCC using …

Circulating microRNA, miR-122 and miR-221 signature in Egyptian ...

Web22 ago 2024 · HCC is a complex disease with multiple pathogenic mechanisms caused by a variety of risk factors, making it difficult to characterize with a single biomarker. In fact, numerous biomarkers have … WebThe most commonly used tumor marker in hepatocellular carcinoma (HCC) is serum alpha-fetoprotein (AFP). It has been routinely used for monitoring the prognosis of … harish singh orahi

HCC with low- and normal serum alpha-fetoprotein levels

WebHCC, Turkey, AFP, MTD, PVT Introduction Alpha-fetoprotein (AFP) was first described in 1953 as a fetal form of albumin and as a marker for HCC [ 1 - 3 ], which opened up the relationship between oncogenesis and embryogenesis. Since then, it has become the best-described and most used marker in HCC. WebResults: D-dimer levels in HCC patients with PVT were significantly higher vs HCC patients without PVT, P <0.002, and vs controls, P <0.001. Conclusion: Plasma D-dimer is a sensitive marker of fibrin turnover and allows for the recognition of activated coagulation which may be manifested in HCC with PVT. Keywords: hepatocellular carcinoma, D ... WebBackground: The hepatocellular carcinoma is one of the most common malignant tumors and carries a poor survival rate. The management of patients at risk for developing HCC … harish singhal modec

Serum human endothelial cell-specific molecule-1 (endocan) and …

Serum markers for hepatocellular carcinoma - Clark - 2016

Web13 ago 2015 · Multivariate forward stepwise regression analysis for significant parameters showed that among the studied parameters CCL4 and CCL5 (P=0.001) are diagnostic markers of HCC. Serum levels of TPO and ... Web31 ott 2024 · This article provides a comprehensive review of the applications of nanotechnology in HCC in recent years: (I) in radiological imaging, magnetic resonance … changing floorboardsWebWe aimed to conduct a direct comparison of five representative serum biomarkers for detecting HCC and to derive multi-marker prediction algorithms. Patients and methods: In total, 846 patients were recruited from three hospitals in China, including 202 HCC patients, 226 liver cirrhosis patients, 215 chronic hepatitis B virus-infected patients, and 203 … changing floppy qemu

"Web1 apr 2004 · Abstract. For detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis, serum alpha-fetoprotein has been widely used, but its sensitivity has not been … " - Hcc serum marker

Hcc serum marker

Assessment of Pivka II as Tumour Marker in Hepatocellular …

WebAdditionally, GP73 showed greater sensitivity than AFP for detecting early-stage HCC and a 57% sensitivity for detecting AFP-negative HCC, suggesting its value as a diagnostic marker for early-stage and/or AFP-negative HCC. 12 A study of 535 patients with HCC or other chronic liver diseases found that all patients had high levels of GP73, 13 … Web10 apr 2024 · The authors evaluated whether the formerly identified HCC-discriminant chemokines were robust earlydetection, HCC stages, Given that chemokines might serve as marker of earlyinHCC the authors aimed defined as BCLC 0 (very early stage) and BCLC (early whenwith compared sera evaluate whether these chemokines mightAalso …

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Web1 dic 2024 · Glypican-3 (GPC3), a member of the glypican family that attaches to the cell surface by a glycosylphosphatidylinositol anchor, is overexpressed in HCC cases and is … Web13 feb 2024 · The alpha-fetoprotein (AFP) in serum is currently available diagnostic marker for HCC discovery. As for patients with chronic liver disease, a sustained increase in AFP serum level was shown to be one of the risk factors of HCC and has been used to help identify high-risk subgroup of chronic liver disease [ 12 ].

WebHCC and their clinical impact is probably going to increase. Key words: hepatocellular carcinoma, serum markers, molecular markers L’epatocarcinoma (HCC) rappresenta attualmente nei Paesi Occidentali la prima causa di morte nei pazienti affetti da cirrosi e la sua frequenza è in costante au- Web1 nov 2024 · HCC surveillance guidelines recommend the use of imaging methods such as CT scan, MRI or ultrasound (US) alone or in combination with the measurement of …

Web1 ago 2012 · CgA is an acidic glycoprotein contained in secretory granules of neuroendocrine cells. 203 Many studies show high serum CgA concentration in patients with HCC, suggesting that CgA might represent a useful marker for HCC. 204 CgA levels are increased in other malignancies such as pancreatic and prostate cancer. 205, 206 … WebNational Center for Biotechnology Information

Web19 ott 2024 · Introduction: serum alpha-fetoprotein (AFP) was routinely employed as a tumor marker for screening, diagnosis, and treatment follow-up of hepatocellular …

Web29 giu 2024 · Background The heterogeneous nature of human hepatocellular carcinoma (HCC) impedes both treatment strategies and prognostic predictions. Several markers have been proposed for the diagnosis of HCC. Cytoskeleton-associated proteins have been known as cellular integrators in neoplasm formation. Hepatic progenitor cells are thought … harish singh parmarWeb27 ago 2024 · Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world owing to limitations in its prognosis. The current prognosis approaches … changing flower color lipstickWeb1 gen 2014 · Serum tumor markers for detecting HCC are classified into 4 groups: oncofetal and glycoprotein antigens, enzymes or isoenzymes, genes, and cytokines. α-Fetoprotein (AFP) and des-γ-caroboxy prothrombin (DCP), also called protein induced by vitamin-K absence or antagonist-II, are 2 representative tumor markers for HCC. changing flooring directionWeb26 mar 2010 · Serum proteomics, through the study of serum protein profiling, is useful in the detection of new biomarkers for early HCC diagnosis. Serum proteomics aims to … changing floors in houseWeb21 gen 2024 · HCC is the leading cause of death in patients with cirrhosis, with an annual HCC incidence of 1–6% 29. The major risk factors for HCC include chronic alcohol consumption, diabetes or... harish singh srinetWebRecently, several serum markers that can be used as noninvasive tools have been identified in human cancers, including HCC. 7–10 Among them, there has been great interest in the aspartate aminotransferase-to-platelet ratio index (APRI) because it is an inexpensive and feasible test that can be used for daily oncologic practice. changing flood light bulbWebThe diagnostic efficacy of serum CHI3L1 level on liver cirrhosis showed the sensitivity of 64.4% and the specificity of 96.7%. The diagnostic efficacy of serum CHI3L1 level on HCC showed the sensitivity of 86.8% and the specificity of 97.8%. Serum CHI3L1 level was higher in Child–Pugh grade B and C patients than in Child–Pugh grade A ... harish singh rawat