WebJun 30, 2024 · Overproduction of 1,2-propanediol and isobutanol in WT using OptForceMUST by iCW773. Funding. National Hi-Tech Research and Development Program of China. History. Usage metrics. Read the peer-reviewed publication. A new genome-scale metabolic model of Corynebacterium glutamicum and its application. Biotechnology for … WebFurthermore, genetic interventions for overproducing l-lysine, 1,2-propanediol and isobutanol simulated using OptForceMUST were in accordance with reported experimental results, indicating the practicability of iCW773 for the design of metabolic networks to overproduce desired products. In vivo genetic modifications of iCW773predicted targets ...
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WebJun 28, 2011 · About. Expert in developing analytics and algorithms for Cell Engineering using CRISPRs, TALENs, RNAi and other technologies, NGS analysis and Machine Learning models. Technical Experience: NGS ... WebThe OptForceMUST algorithm was used in iCW773 to determine genetic interventions by using flux balance analysis. Enhancement of the HA biosynthesis pathway and attenuation of the glycolysis pathway, the pentose phosphate pathway and the dehydrogenation of pyruvate were predicted as targets for genetic modulations. sena industrial riohacha
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